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Brian Strahl's lab focuses on the role of histone modifications. The long-term goal of the Strahl lab is to understand how the distinct types of modifications known to occur on histones contribute to a possible ‘histone code’ (Strahl & Allis 2000) and to human biology and disease.
Professor
The University of North Carolina at Chapel Hill
December 2001 – Present UNC Chapel Hill, NC
Brian Strahl is a faculty member in the Department of Biochemistry and Biophysics at UNC-Chapel Hill. His research centers on the role of histones, and the chemical modifications that occur on them, in regulating the structure and function of chromatin. With his colleagues, Dr. Strahl is exploring the role of enzymes that either "write" or "erase" histone marks, in addition to studying the proteins that associate with them. One new area of Dr. Strahl's lab is the use of histone peptide arrays to determine how combinatorial histone modifications contribute to a possible 'histone code'. This code is thought to govern the organization of chromatin as well as regulate the accessibility of the underlying DNA.
Postdoctoral Fellow
University of Virginia
August 1998 – December 2001 Charlottesville, Virginia
Postdoctoral Fellow with David Allis. In Dr. Allis' lab, Brian D. Strahl worked on identifying and characterizing the enzymes that methylate histones. Dr. Strahl, with Dr. Allis, also proposed the histone code hypothesis.
Ph.D.
North Carolina State University
August 1993 – July 1998 Raliegh, North Carolina
Brian Strahl was a graduate student in the Biochemistry Department at North Carolina State. There, Brian worked under Dr. William L. Miller and studied the transcriptional regulation of the Follicle Stimulating Hormone beta gene.
B.A.
UNC Greensboro
August 1988 – July 1993 Greensboro, North Carolina
Brian Strahl obtained his B.A. in Chemistry and also a second degree in Biology. He worked under the mentorship of Dr. Julian Lombardi, where Dr. Strahl obtained an interest for scientific discovery.
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English
Skills
Epigenetics and chromatin biology
2009 Recipient of the Ruth and Phillip Hettleman Prize for Artistic and Scholarly Achievement, UNC
2008 Recipient of an Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) award from the NIH
2006 Named as a Jefferson-Pilot Fellow in Academic Medicine, UNC
2006 Recipient of the University of North Carolina at Greensboro Young Alumni Award
2005 Recipient of the North Carolina State University Outstanding Alumnus Award
Brian Strahl's CV
Work​
experience​
Awards and Honors
Brian Strahl
Summary